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Poly A Binding Protein Interacting Protein 2 (PAIP2)

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PAIP2A; Polyadenylate-Binding Protein-Interacting Protein 2

Poly A Binding Protein Interacting Protein 2 (PAIP2)
CCC H458
HGNC 17970
MGI 1915119
PubMed 11172725
RGD 1359176
UniProt Q9BPZ3
Wiki PAIP2
By Far Western interaction cloning using human PABP as the probe and a placenta cDNA expression library, Khaleghpour et al. (2001) isolated a 1.4-kb cDNA encoding PAIP2. The highly acidic (predicted pI of 3.9), 127-amino acid protein has a predicted molecular mass of 14.5 kD and acts as a repressor of translation both in vitro and in vivo.
PAIP2 preferentially inhibited translation of a poly(A)-containing mRNA but had no effect on the translation of hepatitis C virus mRNA, which is cap and eIF4G independent. The authors showed that PAIP2 decreases the affinity of PABP for poly(A) RNA and disrupts the repeating structure of poly(A) ribonucleoprotein. Furthermore, PAIP2 was found to compete with PAIP1 (605184) for PABP binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Binding Protein Interacting Protein 2 (PAIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Binding Protein Interacting Protein 2 (PAIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Binding Protein Interacting Protein 2 (PAIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Binding Protein Interacting Protein 2 (PAIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Binding Protein Interacting Protein 2 (PAIP2) ELISA Kit Customized Service Offer
  1. "Translational repression by a novel partner of human poly(A) binding protein, Paip2."Mol. Cell 7:205-216(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Dual interactions of the translational repressor Paip2 with poly(A) binding protein."Mol. Cell. Biol. 21:5200-5213(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B."RNA 12:1556-1568(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and function of the C-terminal PABC domain of human poly(A)-binding protein."Proc. Natl. Acad. Sci. U.S.A. 98:4409-4413(2001) [PubMed] [Europe PMC] [Abstract]