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p21 Protein Activated Kinase 3 (PAK3)

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CDKN1A; MRX30; MRX47; OPHN3; PAK3beta; bPAK; hPAK3; Oligophrenin-3; Mental Retardation,X-Linked 47; Serine/threonine-protein kinase PAK 3

p21 Protein Activated Kinase 3 (PAK3)
CCC H465
HGNC 8592
MGI 1339656
PubMed 20616055
RGD 3251
UniProt O75914
Wiki PAK3
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.PAK3 forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 3 (PAK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 3 (PAK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 3 (PAK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 3 (PAK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 3 (PAK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 3 (PAK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 3 (PAK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 3 (PAK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 3 (PAK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 3 (PAK3) ELISA Kit Customized Service Offer
  1. "PAK3 mutation in nonsyndromic X-linked mental retardation."Nat. Genet. 20:25-30(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees."Mol. Biol. Evol. 20:1281-1289(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties."J. Neurochem. 106:1184-1197(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity."J. Biol. Chem. 276:17347-17353(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases."J. Biol. Chem. 277:5644-5650(2002) [PubMed] [Europe PMC] [Abstract]
  8. "DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3."J. Neurosci. 23:6914-6927(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway."J. Biol. Chem. 286:6470-6478(2011) [PubMed] [Europe PMC] [Abstract]
  11. "PAK signalling in neuronal physiology."Cell. Signal. 21:384-393(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation."Am. J. Med. Genet. 93:294-298(2000) [PubMed] [Europe PMC] [Abstract]
  13. "X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3."Am. J. Med. Genet. A 120:509-517(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]