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p21 Protein Activated Kinase 6 (PAK6)

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PAK5; Serine/threonine-protein kinase PAK 6

p21 Protein Activated Kinase 6 (PAK6)
CCC H466
HGNC 16061
MGI 2679420
PubMed 11773441
RGD 1306213
UniProt Q9NQU5
Wiki PAK6
PAK6 encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway.
The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 6 (PAK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 6 (PAK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 6 (PAK6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 6 (PAK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 6 (PAK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 6 (PAK6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 6 (PAK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 6 (PAK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 6 (PAK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 6 (PAK6) ELISA Kit Customized Service Offer
  1. "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6."J. Biol. Chem. 276:15345-15353(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "AR and ER interaction with a p21-activated kinase (PAK6)."Mol. Endocrinol. 16:85-99(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling."J. Biol. Chem. 279:1922-1931(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase."J. Biol. Chem. 280:3323-3330(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins."Prostate 68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells."Prostate 70:807-816(2010) [PubMed] [Europe PMC] [Abstract]
  10. "The crystal structure of human CDC42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)."Submitted (JAN-2007) to the PDB data bank
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]