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p21 Protein Activated Kinase 2 (PAK2)

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PAK65; PAKgamma; p58; S6/H4 Kinase; Serine/threonine-protein kinase PAK 2

p21 Protein Activated Kinase 2 (PAK2)
CCC H468
HGNC 8591
MGI 1339984
PubMed 7744004
RGD 61953
UniProt Q13177
Wiki PAK2
PAK2 shares 73% amino acid identity with rat brain Pak65, including more than 95% identity within the kinase domain; PAK2 also shares homology with the yeast Ste20 gene. PAK2 is ubiquitously expressed, with highest levels detected in skeletal muscle, ovary, thymus, and spleen. PAK2 transcripts of 7.5, 5, 4.4, and 3 kb were detected in most tissues. The 7.5-kb transcript was predominant in all tissues tested except muscle, where the 7.5- and 3-kb transcripts were equally expressed. In brain, a 3.3-kb transcript was expressed. the multiple PAK2 mRNAs result from alternative splicing. Western blot analysis using an antibody against rat brain Pak65 detected a brain-specific PAK protein, whereas a human PAK2 antibody detected PAK proteins in heart, kidney, liver, and very strongly in purified neutrophil PAK2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH468Hu01 Recombinant p21 Protein Activated Kinase 2 (PAK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH468Hu01 Polyclonal Antibody to p21 Protein Activated Kinase 2 (PAK2) WB,IHC
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 2 (PAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 2 (PAK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 2 (PAK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 2 (PAK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 2 (PAK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 2 (PAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 2 (PAK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 2 (PAK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 2 (PAK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 2 (PAK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 2 (PAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 2 (PAK2) ELISA Kit Customized Service Offer
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  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
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  20. "Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration."Mol. Biol. Cell 21:287-301(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification."J. Biol. Chem. 286:2689-2695(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity."J. Biol. Chem. 286:13603-13611(2011) [PubMed] [Europe PMC] [Abstract]
  25. "P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation."Carcinogenesis 32:659-666(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly."Genes Dev. 25:1359-1364(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
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  29. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold."Nature 469:107-111(2011) [PubMed] [Europe PMC] [Abstract]