P Antigen Family, Member 1 (PAGE1)

GAGEB1 encodes a 143-amino acid polypeptide that contains 6 potential casein kinase phosphorylation sites, 1 potential protein kinase C phosphorylation site, and 3 potential N-myristoylation sites. Northern blot analysis revealed that GAGEB1 is expressed in the placenta and testis. Levels of GAGEB1 mRNA were correlated to the degree of tumorigenicity of prostate cancer cell lines, but were unaffected by androgen treatment.

Northern blot analysis detected a transcript of about 500 nucleotides expressed predominantly in placenta, fallopian tube, and prostate, and at lower levels in testis and uterus. It was also expressed in uterine cancers but not expressed in other normal or cancer tissues examined. RNA dot-blot analysis and RT-PCR confirmed expression predominantly in reproductive tissues.