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Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2)

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SDPII; Syndapin II

Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2)
CCC H473
HGNC 8571
MGI 1345153
PubMed 22846425
RGD 69411
UniProt Q9UNF0
Wiki PACSIN2
The complete human PACSIN2 encodes a deduced 486-amino acid protein that shares 93.6% sequence identity with mouse Pacsin2. The PACSIN2 proteins contain a CDC15 N-terminal domain, a C-terminal SH3 domain, 3 conserved regions specific to the PACSIN family, and 3 asn-pro-phe (NPF) motifs, which potentially bind to EH domains. The PACSIN2 proteins share high sequence similarity with chicken FAP52 and mouse Pacsin1. Pacsin2 expression in all tissues examined, with the highest levels in brain, heart, skeletal muscle, and ovary. Immunofluorescence microscopy of recombinant Pacsin2 expressed in fibroblasts showed a broad, vesicle-like cytoplasmic distribution that appeared to partially overlap with the distributions of both the actin filament and microtubule networks.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C And Casein Kinase Substrate In Neurons 2 (PACSIN2) ELISA Kit Customized Service Offer
  1. "PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins."FEBS Lett. 454:356-362(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis."J. Cell Sci. 113:4511-4521(2000) [PubMed] [Europe PMC] [Abstract]
  7. "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family."Gene 262:199-205(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting."J. Cell Sci. 124:2032-2040(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration."J. Cell Sci. 124:2375-2388(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization."J. Biol. Chem. 287:43438-43453(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Versatile membrane deformation potential of activated pacsin."PLoS ONE 7:E51628-E51628(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis."Mol. Biol. Cell 24:1776-1790(2013) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin."Proc. Natl. Acad. Sci. U.S.A. 106:12700-12705(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II."FEBS Lett. 584:1111-1118(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules."J. Biol. Chem. 287:22387-22396(2012) [PubMed] [Europe PMC] [Abstract]