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Ovary Specific Acidic Protein (OSAP)

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C4orf49; CESP1; HUMMR; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Corneal endothelium-specific protein 1

Ovary Specific Acidic Protein (OSAP)
CCC H495
HGNC 29969
MGI 1914999
PubMed 22359819
RGD 1586369
UniProt Q8TDB4
Ovary-specific acidic protein (OSAP) is a novel molecule discovered from a genomic project designed to identify ovary-selective genes in mice. OSAP silencing by specific small interfering RNAs significantly inhibits 8-bromoadenosine-cAMP-induced progesterone production in Y-1 cells.
Reduction in OSAP levels results in mitochondrial fragmentation and a decrease in the cellular content of mitochondrial DNA, indicative of decreased mitochondrial abundance. Lastly, 8-bromoadenosine-cAMP does not regulate OSAP protein expression in Y-1 cells as is the case for other steroidogenic components known to be induced by cAMP. Collectively these results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovary Specific Acidic Protein (OSAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovary Specific Acidic Protein (OSAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovary Specific Acidic Protein (OSAP) Polyclonal Antibody Customized Service Offer
Assay Kits SEH495Hu ELISA Kit for Ovary Specific Acidic Protein (OSAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovary Specific Acidic Protein (OSAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovary Specific Acidic Protein (OSAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovary Specific Acidic Protein (OSAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ovary Specific Acidic Protein (OSAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ovary Specific Acidic Protein (OSAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovary Specific Acidic Protein (OSAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovary Specific Acidic Protein (OSAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovary Specific Acidic Protein (OSAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ovary Specific Acidic Protein (OSAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ovary Specific Acidic Protein (OSAP) ELISA Kit Customized Service Offer
  1. "Construction of human corneal endothelial cDNA library and identification of novel active genes."Invest. Ophthalmol. Vis. Sci. 43:1749-1756(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The generation and characterization of an ovary-selective cDNA library."Mol. Cell. Endocrinol. 202:67-69(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Distribution of CESP-1 protein in the corneal endothelium and other tissues."Invest. Ophthalmol. Vis. Sci. 47:1397-1403(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis."Endocrinology 150:3353-3359(2009) [PubMed] [Europe PMC] [Abstract]
  6. "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."J. Cell Biol. 185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The expression of a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is under the regulation of the HPG axis."Endocrinology 152:2311-2320(2011) [PubMed] [Europe PMC] [Abstract]