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Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1)

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JC7; NUCKS; P1

Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1)
CCC H512
HGNC 29923
MGI 1934811
PubMed 23065711
RGD 620993
UniProt Q9H1E3
Wiki NUCKS1
The deduced human and rat proteins contain 243 amino acids and share 95.1% sequence identity. By immunoblotting of intracellular fractions and fluorescence microscopy of HEK-293 cells expressing NUCKS1-GFP, Ostvold et al. (2001) determined that NUCKS1 is a nuclear protein. Grundt et al. (2004) found NUCKS1 orthologs in several species from zebrafish to mouse, all of which encoded highly conserved proteins compared to human NUCKS1. No orthologs were found in insects or yeast, suggesting that NUCKS1 is a vertebrate gene. The conserved regions of NUCKS1 contain several consensus phosphorylation sites for casein kinase II (CK2) and cyclin-dependent kinases, 2 putative nuclear localization signals, and the basic DNA-binding domain. The N terminus is extremely well conserved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 (NUCKS1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo."Eur. J. Biochem. 268:2430-2440(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species."Biochem. Biophys. Res. Commun. 323:796-801(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]