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Nurim (NRM)

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NRM29; Nuclear Envelope Membrane Protein; Nuclear rim protein

Nurim (NRM)
CCC H518
HGNC 8003
MGI 2146855
PubMed 10402458
RGD 1302966
UniProt Q8IXM6
Nurim is an inner nuclear membrane (INM) protein that was first isolated in a visual screen for nuclear envelope-localizing proteins. Nurim lacks an N-terminal domain characteristic of other INM proteins examined to date and may represent a class of proteins that localize to the INM by a distinct mechanism.
Results from immunoprobing and protease protection assays together with other analyses indicate that nurim is a six transmembrane-spanning protein and contains a hairpin turn in its C-terminal transmembrane domain, resulting in the N and C termini residing on the same side of the membrane. In biochemical fractionation, nurim remained extremely tightly bound to nuclear fractions and was released in significant quantities only in the presence of 4 m urea.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nurim (NRM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nurim (NRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nurim (NRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nurim (NRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nurim (NRM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nurim (NRM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nurim (NRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nurim (NRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nurim (NRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nurim (NRM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nurim (NRM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nurim (NRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nurim (NRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nurim (NRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nurim (NRM) ELISA Kit Customized Service Offer
  1. "The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis."Curr. Mol. Med. 12:1372-1382(2012) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein."J. Cell Biol. 146:29-44(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane."J. Biol. Chem. 280:2512-2521(2005) [PubMed] [Europe PMC] [Abstract]