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NFKB Activating Protein (NKAP)

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NF Kappa B Activating Protein

NFKB Activating Protein (NKAP)
CCC H538
HGNC 29873
MGI 1914300
PubMed 24353314
RGD 1565955
UniProt Q8N5F7
Wiki NKAP
NKAP is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.The predicted 415-amino acid protein is highly charged and basic. It is highly conserved in evolution and shares 90% amino acid identity with mouse Nkap. Immunofluorescence microscopy demonstrated nuclear expression of endogenous and overexpressed NKAP in 293 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NFKB Activating Protein (NKAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NFKB Activating Protein (NKAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NFKB Activating Protein (NKAP) Polyclonal Antibody Customized Service Offer
Assay Kits SEH538Hu ELISA Kit for NFKB Activating Protein (NKAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NFKB Activating Protein (NKAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NFKB Activating Protein (NKAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NFKB Activating Protein (NKAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NFKB Activating Protein (NKAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for NFKB Activating Protein (NKAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH538Ra01 Recombinant NFKB Activating Protein (NKAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH538Ra21 Monoclonal Antibody to NFKB Activating Protein (NKAP) WB; IHC; ICC; IP.
PAH538Ra01 Polyclonal Antibody to NFKB Activating Protein (NKAP) WB; IHC; ICC; IP.
Assay Kits SEH538Ra ELISA Kit for NFKB Activating Protein (NKAP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a nuclear protein that promotes NF-kappaB activation."Biochem. Biophys. Res. Commun. 310:720-724(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "NKAP is a transcriptional repressor of notch signaling and is required for T cell development."Immunity 30:696-707(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]