Neuronal Guanine Nucleotide Exchange Factor (NGEF)
[Edit]ARHGEF27; Ephexin 1; Eph-interacting exchange protein
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Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. The predicted 620-amino acid mouse ephexin protein contains a tandem Dbl homology-pleckstrin homology (DH-PH) motif and a C-terminal SH3 domain.
Mouse Ngef is 95% identical to the 527-amino acid partial human sequence. Northern blot analysis revealed expression of a 2.8-kb transcript in mouse and human brain, with predominant expression in caudate nucleus and lower expression in amygdala and hippocampus. Analysis of mouse embryos detected strong expression on day 7 and relatively little expression at later stages of gestation. Functional analysis suggested that mouse Ngef has transforming potential.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuronal Guanine Nucleotide Exchange Factor (NGEF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuronal Guanine Nucleotide Exchange Factor (NGEF) | ELISA Kit Customized Service Offer |
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