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Never In Mitosis Gene A Related Kinase 3 (NEK3)

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HSPK36; Phosphorylase B Kinase Kinase; Glycogen Synthase A Kinase; Hydroxyalkyl-Protein Kinase; Serine/threonine-protein kinase Nek3

Never In Mitosis Gene A Related Kinase 3 (NEK3)
CCC H560
HGNC 7746
MGI 1344371
PubMed 15618286
RGD 1307419
UniProt P51956
Wiki NEK3
In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events.
NEK3 encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 3 (NEK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 3 (NEK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 3 (NEK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 3 (NEK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 3 (NEK3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)."Cytogenet. Cell Genet. 95:177-182(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans."Cell Growth Differ. 5:625-635(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans."Cell Growth Differ. 4:821-830(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells."Oncogene 26:4668-4678(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]