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Nuclear Cap Binding Protein Subunit 2 (NCBP2)

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NIP1; CBP20; Cbc2; PIG55; 20 kDa nuclear cap-binding protein; Cell proliferation-inducing gene 55 protein; NCBP-interacting protein 1

Nuclear Cap Binding Protein Subunit 2 (NCBP2)
CCC H564
HGNC 7659
MGI 1915342
PubMed 11551508
UniProt P52298
NCBP2 is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. Sequence analysis of the deduced 156-amino acid NCBP2 protein, which shares 84% amino acid identity with the Xenopus Ncbp2 protein, predicted that it contains an RNP motif with highly conserved RNP1 and RNP2 domains. Northern blot analysis detected a major 2.0- and a minor 0.8-kb NCBP2 transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Cap Binding Protein Subunit 2 (NCBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Cap Binding Protein Subunit 2 (NCBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Cap Binding Protein Subunit 2 (NCBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Cap Binding Protein Subunit 2 (NCBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Cap Binding Protein Subunit 2 (NCBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Cap Binding Protein Subunit 2 (NCBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Cap Binding Protein Subunit 2 (NCBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Cap Binding Protein Subunit 2 (NCBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Cap Binding Protein Subunit 2 (NCBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Cap Binding Protein Subunit 2 (NCBP2) ELISA Kit Customized Service Offer
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  8. "Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20."Cell 106:607-617(2001) [PubMed] [Europe PMC] [Abstract]
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  15. "Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation."Cell 138:328-339(2009) [PubMed] [Europe PMC] [Abstract]
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