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Neuroblastoma Amplified Sequence (NBAS)

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NAG; Neuroblastoma-amplified gene protein

Neuroblastoma Amplified Sequence (NBAS)
CCC H580
HGNC 15625
MGI 1918419
PubMed 20577004
UniProt A2RRP1
The deduced 1,352-amino acid protein contains a leucine zipper domain and a ribosomal protein S14 signature domain in its C-terminal half. Northern blot analysis detected a 4.5-kb transcript in neuroblastoma cell lines. RNA dot blot analysis detected expression in all tissues examined, with strongest expression in adult testis, pancreas, pituitary, and adrenal gland, and in fetal heart, kidney, liver, and lung.
NAG amplified in 5 of 8 (63%) MYCN-amplified neuroblastoma cell lines and in 9 of 13 (70%) MYCN-amplified neuroblastoma tumors. Tumors that did not show MYCN amplification lacked NAG amplification. Northern blot analysis determined that amplification of the NAG gene correlated with increased NAG expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuroblastoma Amplified Sequence (NBAS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuroblastoma Amplified Sequence (NBAS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroblastoma Amplified Sequence (NBAS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroblastoma Amplified Sequence (NBAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroblastoma Amplified Sequence (NBAS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuroblastoma Amplified Sequence (NBAS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuroblastoma Amplified Sequence (NBAS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroblastoma Amplified Sequence (NBAS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroblastoma Amplified Sequence (NBAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroblastoma Amplified Sequence (NBAS) ELISA Kit Customized Service Offer
  1. "The neuroblastoma amplified gene, NAG: genomic structure and characterisation of the 7.3 kb transcript predominantly expressed in neuroblastoma."Gene 307:1-11(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma."Oncogene 18:233-238(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon."J. Med. Genet. 37:501-509(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger-Huet anomaly."J. Med. Genet. 47:538-548(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]