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MAX Interactor 1 (MXI1)

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MAD2; MXD2; MXI; bHLHc11; Class C basic helix-loop-helix protein 11

MAX Interactor 1 (MXI1)
CCC H599
HGNC 7534
MGI 97245
PubMed 9624006
RGD 3128
UniProt P50539
Wiki MXI1
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers.
MXI1 is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAX Interactor 1 (MXI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAX Interactor 1 (MXI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAX Interactor 1 (MXI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAX Interactor 1 (MXI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAX Interactor 1 (MXI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAX Interactor 1 (MXI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAX Interactor 1 (MXI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAX Interactor 1 (MXI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAX Interactor 1 (MXI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAX Interactor 1 (MXI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAX Interactor 1 (MXI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAX Interactor 1 (MXI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAX Interactor 1 (MXI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAX Interactor 1 (MXI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAX Interactor 1 (MXI1) ELISA Kit Customized Service Offer
  1. "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites."Cell 72:223-232(1993) [PubMed] [Europe PMC] [Abstract]
  2. ErratumCell 79:388-388(1994)
  3. "Genomic organization of human MXI1, a putative tumor suppressor gene."Genomics 32:466-470(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Expression, regulation and polymorphism of the mxi1 genes."Gene 176:45-48(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas."Hum. Genet. 95:709-711(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Mutation of the MXI1 gene in prostate cancer."Nat. Genet. 9:249-255(1995) [PubMed] [Europe PMC] [Abstract]