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M-Phase Phosphoprotein 8 (MPHOSPH8)

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Mpp8; HSMPP8; TWA3; Two hybrid-associated protein 3 with RanBPM

M-Phase Phosphoprotein 8 (MPHOSPH8)
CCC H623
HGNC 29810
MGI 1922589
PubMed 17081983
RGD 1305133
UniProt Q99549
Wiki MPHOSPH8
Using N-terminally truncated RANBPM (RANBP9) as bait in a yeast 2-hybrid screen of a human lymphocyte cDNA library, Umeda et al. (2003) obtained a partial cDNA encoding the C-terminal half of MPHOSPH8, which they called TWA3.The International Radiation Hybrid Mapping Consortium mapped the MPHOSPH8 gene to chromosome 13.
Using yeast 2-hybrid analysis, Umeda et al. (2003) showed that N-terminally truncated RANBPM interacted with TWA1 (C20ORF11), MPHOSPH8, and muskelin (MKLN1). Coimmunoprecipitation and gel filtration analyses demonstrated that endogenous Ranbpm and Twa1 interacted in COS-7 cells, and both proteins interacted with GST-fused human muskelin in a 670-kD protein complex in transfected COS-7 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 8 (MPHOSPH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 8 (MPHOSPH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 8 (MPHOSPH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 8 (MPHOSPH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 8 (MPHOSPH8) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of novel M phase phosphoproteins by expression cloning."Mol. Biol. Cell 7:1455-1469(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion."EMBO J. 29:3673-3687(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding."J. Mol. Biol. 408:807-814(2011) [PubMed] [Europe PMC] [Abstract]
  17. "MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a."Nat. Commun. 2:533-533(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9."PLoS ONE 6:E25104-E25104(2011) [PubMed] [Europe PMC] [Abstract]