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N-Methylpurine DNA Glycosylase (MPG)

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AAG; APNG; ADPG; CRA36.1; MDG; Mid1; PIG11; PIG16; Anpg; DNA-3-Methyladenine Glycosylase; Alkyladenine DNA Glycosylase; 3-alkyladenine DNA glycosylase

N-Methylpurine DNA Glycosylase (MPG)
CCC H625
HGNC 7211
MGI 97073
PubMed 21377995
RGD 3106
UniProt P29372
Wiki MPG
The bacterial enzyme 3-methyladenine (3MeA) DNA glycosylase repairs the lethal lesion 3MeA that blocks DNA replication in Escherichia coli. The removal of 3MeA is mediated by two 3MeA DNA glycosylases in E. coli, encoded by the alkA and tag genes.
The cDNA hybridized to human genomic DNA but did not hybridize to E. coli or yeast DNA. DNA sequence analysis defined an open reading frame coding for a 33-kD protein that showed extensive amino acid homology with rat 3MeA DNA glycosylase. The gene (designated N-methylpurine DNA glycosylase, MPG) was mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH625Hu01 Recombinant N-Methylpurine DNA Glycosylase (MPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH625Hu01 Polyclonal Antibody to N-Methylpurine DNA Glycosylase (MPG) WB; ICC; IHC-P; IHC-F; ELISA.
MAH625Hu21 Monoclonal Antibody to N-Methylpurine DNA Glycosylase (MPG) WB; IHC; ICC; IP.
Assay Kits SEH625Hu ELISA Kit for N-Methylpurine DNA Glycosylase (MPG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH625Mu01 Recombinant N-Methylpurine DNA Glycosylase (MPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH625Mu01 Polyclonal Antibody to N-Methylpurine DNA Glycosylase (MPG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for N-Methylpurine DNA Glycosylase (MPG) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Methylpurine DNA Glycosylase (MPG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH625Ra01 Recombinant N-Methylpurine DNA Glycosylase (MPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH625Ra01 Polyclonal Antibody to N-Methylpurine DNA Glycosylase (MPG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for N-Methylpurine DNA Glycosylase (MPG) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Methylpurine DNA Glycosylase (MPG) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16."Proc. Natl. Acad. Sci. U.S.A. 88:9127-9131(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere."Proc. Natl. Acad. Sci. U.S.A. 90:3437-3441(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase."J. Biol. Chem. 266:15710-15715(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine."Biochem. Biophys. Res. Commun. 176:1170-1177(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse."Mamm. Genome 4:314-323(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin."Proc. Natl. Acad. Sci. U.S.A. 100:12859-12864(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)."DNA Repair 12:177-187(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision."Cell 95:249-258(1998) [PubMed] [Europe PMC] [Abstract]