≡

Modulator Of Apoptosis 1 (MOAP1)

[Edit]

MAP-1; PNMA4; Paraneoplastic antigen Ma4

Modulator Of Apoptosis 1 (MOAP1)
CCC H633
HGNC 16658
MGI 1915555
PubMed 22434376
RGD 1585155
UniProt Q96BY2
Wiki MOAP1
MOAP1 was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.
MAP1 formed homodimers, and it associated with BAX, BCL2, and BCLXL (BCL2L1) in vitro and in transfected human embryonic kidney cells. MAP1 did not bind other members of the BCL2 family. Mutation analysis indicated that the BH3-like domain of MAP1 was required to mediate apoptosis and for binding of MAP1 to BAX, but not to BCLXL. All 3 BH domains of BAX were required for binding with MAP1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Modulator Of Apoptosis 1 (MOAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Modulator Of Apoptosis 1 (MOAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Modulator Of Apoptosis 1 (MOAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Modulator Of Apoptosis 1 (MOAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Modulator Of Apoptosis 1 (MOAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Modulator Of Apoptosis 1 (MOAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Modulator Of Apoptosis 1 (MOAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Modulator Of Apoptosis 1 (MOAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Modulator Of Apoptosis 1 (MOAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Modulator Of Apoptosis 1 (MOAP1) ELISA Kit Customized Service Offer
  1. "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains."J. Biol. Chem. 276:2802-2807(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death."Mol. Cell 18:637-650(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
  6. "TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process."Exp. Cell Res. 315:1313-1325(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1."J. Cell Biol. 197:361-367(2012) [PubMed] [Europe PMC] [Abstract]