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MLX Interacting Protein (MLXIP)

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MIR; bHLHe36; MONDOA; Class E basic helix-loop-helix protein 36; Transcriptional activator MondoA

MLX Interacting Protein (MLXIP)
CCC H636
HGNC 17055
MGI 2141183
PubMed 23840567
RGD 1560774
UniProt Q9HAP2
The MONDOA transcript contains an Alu sequence within the 3-prime untranslated region. RT-PCR ELISA detected low to moderate expression in most tissues examined, with highest expression in brain, liver, skeletal muscle, and ovary, and little to no expression in spleen.
The deduced 919-amino acid protein contains a central serine-threonine-proline (STP)-rich domain, a basic helix-loop-helix domain, a zipper region, and a C-terminal MLX homology domain. The N terminus of MONDOA is conserved among MONDO proteins of other species. In situ hybridization of mouse embryos detected broad Mondoa expression, with slightly elevated levels in the developing central nervous system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLX Interacting Protein (MLXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLX Interacting Protein (MLXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLX Interacting Protein (MLXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLX Interacting Protein (MLXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLX Interacting Protein (MLXIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLX Interacting Protein (MLXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLX Interacting Protein (MLXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLX Interacting Protein (MLXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLX Interacting Protein (MLXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLX Interacting Protein (MLXIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLX Interacting Protein (MLXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLX Interacting Protein (MLXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLX Interacting Protein (MLXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLX Interacting Protein (MLXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLX Interacting Protein (MLXIP) ELISA Kit Customized Service Offer
  1. "MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network."Mol. Cell. Biol. 20:8845-8854(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Placenta.
  4. "A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex."Mol. Cell. Biol. 22:8514-8526(2002) [PubMed] [Europe PMC] [Abstract]
  5. "MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis."Mol. Cell. Biol. 26:4863-4871(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]