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Ligand Dependent Nuclear Receptor Corepressor (LCOR)

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MLR2; Mblk1-related protein 2

Ligand Dependent Nuclear Receptor Corepressor (LCOR)
CCC H638
HGNC 29503
MGI 2443930
PubMed 12535528
RGD 1311704
UniProt Q96JN0
Wiki LCOR
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box. The deduced 433-amino acid protein contains a DNA-binding motif and a motif conserved in Mlr1 (LCORL).
The deduced KIAA1795 protein contains 572 amino acids. RT-PCR followed by ELISA detected highest expression in liver, testis, and ovary, followed by kidney and brain. Within brain, highest expression was detected in amygdala, corpus callosum, and caudate nucleus. The predicted 433-amino acid LCOR protein has a calculated molecular mass of approximately 47 kD. It contains an LxxLL motif, a nuclear localization signal, and a helix-loop-helix domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ligand Dependent Nuclear Receptor Corepressor (LCOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ligand Dependent Nuclear Receptor Corepressor (LCOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ligand Dependent Nuclear Receptor Corepressor (LCOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ligand Dependent Nuclear Receptor Corepressor (LCOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ligand Dependent Nuclear Receptor Corepressor (LCOR) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms."Mol. Cell 11:139-150(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Coordinated histone modifications mediated by a CtBP co-repressor complex."Nature 422:735-738(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structures of the HTH domain of human LCOR protein."Submitted (NOV-2005) to the PDB data bank