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MLF1 Interacting Protein (MLF1IP)

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KLIP1; CENP50; CENPU; ICEN24; PBIP1; Centromere Protein U; Centromere protein of 50 kDa; Interphase centromere complex 24; KSHV latent nuclear antigen-interacting protein 1

MLF1 Interacting Protein (MLF1IP)
CCC H639
HGNC 21348
MGI 1919126
PubMed 15116101
RGD 1562566
UniProt Q71F23
Wiki MLF1IP
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA replaces histone H3. MLF1IP, or CENPU, is an additional factor required for centromere assembly. The deduced 418-amino acid protein has a calculated molecular mass of 46 kD. It has 2 bipartite nuclear localization signals, 2 nuclear receptor-binding motifs (LxxLL), 2 leucine zippers, 2 PEST residues, and several potential phosphorylation sites. Expression was highest in adult testis, thymus, bone marrow, and fetal liver, and lower in adult lymph node, placenta, colon, and spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLF1 Interacting Protein (MLF1IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLF1 Interacting Protein (MLF1IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLF1 Interacting Protein (MLF1IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLF1 Interacting Protein (MLF1IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLF1 Interacting Protein (MLF1IP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLF1 Interacting Protein (MLF1IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLF1 Interacting Protein (MLF1IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLF1 Interacting Protein (MLF1IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLF1 Interacting Protein (MLF1IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLF1 Interacting Protein (MLF1IP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MLF1 Interacting Protein (MLF1IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MLF1 Interacting Protein (MLF1IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MLF1 Interacting Protein (MLF1IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MLF1 Interacting Protein (MLF1IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MLF1 Interacting Protein (MLF1IP) ELISA Kit Customized Service Offer
  1. "Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus."J. Virol. 77:9758-9768(2003) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP."Oncogene 23:3700-3707(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma."Brain Res. 1047:56-64(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation."Mol. Cell 24:409-422(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]