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MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2)

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GPRK7; MNK2; G Protein-Coupled Receptor Kinase 7; Putative Map Kinase Interacting Kinase

MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2)
CCC H642
HGNC 7111
MGI 894279
PubMed 22370634
RGD 1305728
UniProt Q9HBH9
Wiki MKNK2
Mnk2 has a conserved C-terminal Erk-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. Northern blot analysis detected Mnk2 expression in all adult mouse tissues tested except brain, where levels were greatly reduced. Expression was especially abundant in skeletal muscle.
The sequence designated GPRK7 showed the least homology to known receptor kinases and was later determined to match the sequence of mitogen-activated protein kinase-interacting serine/threonine kinase-2 (MKNK2). MKNK2 contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Interacting Serine/Threonine Kinase 2 (MKNK2) ELISA Kit Customized Service Offer
  1. "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta."Genomics 69:63-71(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."Mol. Cell. Biol. 21:743-754(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2."Mol. Cell. Biol. 21:5500-5511(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization."Mol. Cell. Biol. 23:5692-5705(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1."Immunity 23:177-189(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha."J. Biol. Chem. 283:57-65(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2."J. Biol. Chem. 283:12034-12042(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach."J. Med. Chem. 53:6618-6628(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction."Mol. Cell. Biol. 30:5160-5167(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses."Mol. Pharmacol. 78:778-784(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E."Neoplasia 12:848-855(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis."J. Biol. Chem. 286:6017-6026(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)."Front. Biosci. 13:5359-5373(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site."Structure 13:1559-1568(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment."EMBO J. 25:4020-4032(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]