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Misshapen Like Kinase 1 (MINK1)

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B55; MAP4K6; MINK; YSK2; ZC3; hMINK; hMINKbeta; Misshapen/NIK-Related Kinase; MAPK/ERK kinase kinase kinase 6; Mitogen-activated protein kinase kinase kinase kinase 6

Misshapen Like Kinase 1 (MINK1)
CCC H647
HGNC 17565
MGI 1355329
PubMed 10708748
RGD 1359135
UniProt Q8N4C8
Wiki MINK1
Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.The deduced protein contains 1,300 amino acids and has a calculated molecular mass of 146 kD. Mink has an N-terminal kinase domain, an intermediate region, and a C-terminal GCK homology domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Misshapen Like Kinase 1 (MINK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Misshapen Like Kinase 1 (MINK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Misshapen Like Kinase 1 (MINK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Misshapen Like Kinase 1 (MINK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Misshapen Like Kinase 1 (MINK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Misshapen Like Kinase 1 (MINK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Misshapen Like Kinase 1 (MINK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Misshapen Like Kinase 1 (MINK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Misshapen Like Kinase 1 (MINK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Misshapen Like Kinase 1 (MINK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Misshapen Like Kinase 1 (MINK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Misshapen Like Kinase 1 (MINK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Misshapen Like Kinase 1 (MINK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Misshapen Like Kinase 1 (MINK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Misshapen Like Kinase 1 (MINK1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development."FEBS Lett. 469:19-23(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta."J. Biol. Chem. 279:54387-54397(2004) [PubMed] [Europe PMC] [Abstract]
  3. ErratumJ. Biol. Chem. 280:5128-5128(2005)
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells."Mol. Cell 20:673-685(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1."Biochem. Biophys. Res. Commun. 377:573-578(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Smad inhibition by the Ste20 kinase Misshapen."Proc. Natl. Acad. Sci. U.S.A. 108:11127-11132(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]