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Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4)

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MGAT4A; GnT-Iva; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa

Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4)
CCC H656
HGNC 7047
MGI 2662992
PubMed 23732644
RGD 1305650
UniProt Q9UM21
MGAT4 encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. The predicted 535-amino acid MGAT4A protein is a type II membrane protein, similar to other known Golgi glycosyltransferases. MGAT4A has 3 potential N-glycosylation sites. Human MGAT4A and bovine GnT-IV share 96% amino acid sequence identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT4) ELISA Kit Customized Service Offer
  1. "Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase."Glycobiology 9:303-310(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain."Cancer Res. 59:3949-3953(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer."Biochem. Biophys. Res. Commun. 341:478-482(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes."Glycoconj. J. 23:473-480(2006) [PubMed] [Europe PMC] [Abstract]