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Methionyl Aminopeptidase 1 (METAP1)

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MAP1; Methionine aminopeptidase 1

Methionyl Aminopeptidase 1 (METAP1)
CCC H664
HGNC 15789
MGI 1922874
PubMed 12144506
RGD 1305545
UniProt P53582
Wiki METAP1
By sequencing clones obtained from a size-fractionated human myeloid leukemia cell line cDNA library, Nagase et al. (1995) cloned METAP1, which they designated KIAA0094. The deduced 394-amino acid protein shares 51.8% amino acid identity with S. cerevisiae Metap1. Northern blot analysis detected intermediate expression of Metap1 in skeletal muscle and low expression in all other tissues and cell lines examined.
The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of solid tumors. One of the leading angiogenic compounds, fumagillin and its derivative TNP-470, inhibits neovascularization via endothelial cell cycle arrest in the late G1 phase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1 (METAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1 (METAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1 (METAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1 (METAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1 (METAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1 (METAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1 (METAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1 (METAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1 (METAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1 (METAP1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Structural basis for the functional differences between type I and type II human methionine aminopeptidases."Biochemistry 44:14741-14749(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases."Angew. Chem. Int. Ed. 45:3772-3775(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression."Proc. Natl. Acad. Sci. U.S.A. 103:18148-18153(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase."Protein Sci. 15:1842-1848(2006) [PubMed] [Europe PMC] [Abstract]