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Lymphocyte Antigen 96 (LY96)

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MD-2; ESOP1

Lymphocyte Antigen 96 (LY96)
CCC H705
HGNC 17156
MGI 1341909
PubMed 21390520
UniProt Q9Y6Y9
Wiki LY96
LY96 is involved in binding lipopolysaccharide with TLR 4. It is also known as "MD2". The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. MD2 did not interact with LY64, but it did appear on cells expressing Toll-like receptor-4 (TLR4). Toll-like receptors, which contain extracellular LRRs and have intracellular regions homologous to the intracellular signaling domain of the interleukin-1 receptor (IL1R), activate nuclear factor kappa-B (NFKB). TLR4 is involved in the response to lipopolysaccharide (LPS) from gram-negative bacteria. Functional analysis showed that expression of MD2 enhanced TLR4-dependent activation of NFKB.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH705Hu01 Recombinant Lymphocyte Antigen 96 (LY96) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH705Hu01 Polyclonal Antibody to Lymphocyte Antigen 96 (LY96) WB; IHC; ICC; IP.
LAH705Hu71 Biotin-Linked Polyclonal Antibody to Lymphocyte Antigen 96 (LY96) WB; IHC; ICC.
MAH705Hu21 Monoclonal Antibody to Lymphocyte Antigen 96 (LY96) WB; IHC; ICC; IP.
Assay Kits SEH705Hu ELISA Kit for Lymphocyte Antigen 96 (LY96) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH705Mu01 Recombinant Lymphocyte Antigen 96 (LY96) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH705Mu01 Polyclonal Antibody to Lymphocyte Antigen 96 (LY96) WB; IHC; ICC; IP.
LAH705Mu71 Biotin-Linked Polyclonal Antibody to Lymphocyte Antigen 96 (LY96) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lymphocyte Antigen 96 (LY96) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Antigen 96 (LY96) ELISA Kit Customized Service Offer
  1. "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4."J. Exp. Med. 189:1777-1782(1999) [PubMed] [Europe PMC] [Abstract]
  2. "ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice."Blood 96:362-364(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular genetic analysis of an endotoxin nonresponder mutant cell line. A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling."J. Exp. Med. 194:79-88(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components."J. Immunol. 166:1938-1944(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4."Proc. Natl. Acad. Sci. U.S.A. 98:12156-12161(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The role of disulfide bonds in the assembly and function of MD-2."Proc. Natl. Acad. Sci. U.S.A. 100:3919-3924(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."Cell 130:906-917(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa."Science 316:1632-1634(2007) [PubMed] [Europe PMC] [Abstract]