Lipopolysaccharide Induced TNF Factor (LITAF)
[Edit]CMT1C; PIG7; SIMPLE; TP53I7; p53-induced gene 7; Small integral membrane protein of lysosome/late endosome; Lipopolysaccharide-induced tumor necrosis factor-alpha factor
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Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators.
LITAF lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lipopolysaccharide Induced TNF Factor (LITAF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lipopolysaccharide Induced TNF Factor (LITAF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lipopolysaccharide Induced TNF Factor (LITAF) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lipopolysaccharide Induced TNF Factor (LITAF) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lipopolysaccharide Induced TNF Factor (LITAF) | ELISA Kit Customized Service Offer |
- "A model for p53-induced apoptosis."Nature 389:300-306(1997) [PubMed] [Europe PMC] [Abstract]
- "A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment."Proc. Natl. Acad. Sci. U.S.A. 96:4518-4523(1999) [PubMed] [Europe PMC] [Abstract]
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- "LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines."Proc. Natl. Acad. Sci. U.S.A. 102:5132-5137(2005) [PubMed] [Europe PMC] [Abstract]
- "Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C."Neurology 60:22-26(2003) [PubMed] [Europe PMC] [Abstract]
- "PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease."Int. J. Cancer 111:218-223(2004) [PubMed] [Europe PMC] [Abstract]
- "Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease."Ann. Neurol. 57:589-591(2005) [PubMed] [Europe PMC] [Abstract]
- "SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation."Hum. Mutat. 25:372-383(2005) [PubMed] [Europe PMC] [Abstract]