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Kv Channel Interacting Protein 4 (KCNIP4)

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CALP; KCHIP4; Potassium channel-interacting protein 4; Calsenilin-like protein; A-type potassium channel modulatory protein 4

Kv Channel Interacting Protein 4 (KCNIP4)
CCC H760
HGNC 30083
MGI 1933131
PubMed 23457522
RGD 708539
UniProt Q6PIL6
Wiki KCNIP4
Kv channel-interacting protein 4 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kv Channel Interacting Protein 4 (KCNIP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 4 (KCNIP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 4 (KCNIP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kv Channel Interacting Protein 4 (KCNIP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 4 (KCNIP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 4 (KCNIP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kv Channel Interacting Protein 4 (KCNIP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kv Channel Interacting Protein 4 (KCNIP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 4 (KCNIP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 4 (KCNIP4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4."J. Biol. Chem. 277:14965-14975(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain."Proc. Natl. Acad. Sci. U.S.A. 99:1035-1040(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family."Genomics 86:581-593(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating."J. Biol. Chem. 283:36046-36059(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Auxiliary KChIP4a suppresses A-type K+ current through endoplasmic reticulum (ER) retention and promoting closed-state inactivation of Kv4 channels."J. Biol. Chem. 288:14727-14741(2013) [PubMed] [Europe PMC] [Abstract]
  9. "The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level."J. Biol. Chem. 289:17597-17609(2014) [PubMed] [Europe PMC] [Abstract]