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Kv Channel Interacting Protein 3 (KCNIP3)

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CSEN; DREAM; KCHIP3; Calsenilin; Presenilin-Binding Protein,EF Hand Transcription Factor; DRE-antagonist modulator; A-type potassium channel modulatory protein 3

Kv Channel Interacting Protein 3 (KCNIP3)
CCC H763
HGNC 15523
MGI 1929258
PubMed 22391450
RGD 70888
UniProt Q9Y2W7
Wiki KCNIP3
Calsenilin is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kv Channel Interacting Protein 3 (KCNIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 3 (KCNIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 3 (KCNIP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kv Channel Interacting Protein 3 (KCNIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 3 (KCNIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 3 (KCNIP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH763Ra01 Recombinant Kv Channel Interacting Protein 3 (KCNIP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH763Ra01 Polyclonal Antibody to Kv Channel Interacting Protein 3 (KCNIP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kv Channel Interacting Protein 3 (KCNIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kv Channel Interacting Protein 3 (KCNIP3) ELISA Kit Customized Service Offer
  1. "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment."Nat. Med. 4:1177-1181(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DREAM is a Ca2+-regulated transcriptional repressor."Nature 398:80-84(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Modulation of A-type potassium channels by a family of calcium sensors."Nature 403:553-556(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family."Genomics 86:581-593(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2."J. Biol. Chem. 276:19197-19204(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Pro-apoptotic function of calsenilin/DREAM/KChIP3."FASEB J. 15:589-591(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling."Mol. Cell. Neurosci. 19:552-559(2002) [PubMed] [Europe PMC] [Abstract]
  11. "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels."J. Biol. Chem. 278:36445-36454(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3."Mol. Cell. Neurosci. 23:495-506(2003) [PubMed] [Europe PMC] [Abstract]
  13. "KChIP3 rescues the functional expression of Shal channel tetramerization mutants."J. Biol. Chem. 279:54542-54551(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure."J. Neurochem. 88:604-611(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties."J. Physiol. (Lond.) 568:767-788(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating."J. Biol. Chem. 283:36046-36059(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Sumoylation regulates nuclear localization of repressor DREAM."Biochim. Biophys. Acta 1813:1050-1058(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin."Protein Sci. 16:2502-2509(2007) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]