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IL2 Inducible T-Cell Kinase (ITK)

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PSCTK2; EMT; LYK; T-cell-specific kinase; Tyrosine-protein kinase Lyk

IL2 Inducible T-Cell Kinase (ITK)
CCC H774
HGNC 6171
MGI 96621
PubMed 8364206
RGD 1311618
UniProt Q08881
Wiki ITK
A single 6.2-kb mRNA and 72-kD protein were detected in T lymphocytes and NK-like cell lines, but were not detected in other cell lineages. Sequence comparisons suggested that the protein is probably the human homolog of a murine interleukin-2-inducible T-cell kinase (ITK). However, unlike ITK, the message and protein levels for the new entity did not vary markedly on stimulation of human IL-2 responsive T cells with IL-2. They referred to the gene and its protein product as EMT. They concluded that EMT is a member of a new family of intracellular kinases that includes BPK. The expression of EMT message and protein in thymocytes and mature T cells, combined with its homology to BPK and its chromosomal localization, suggested that EMT may play a role in thymic ontogeny and growth regulation of mature T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IL2 Inducible T-Cell Kinase (ITK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) Polyclonal Antibody Customized Service Offer
Assay Kits SEH774Hu ELISA Kit for IL2 Inducible T-Cell Kinase (ITK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH774Mu01 Recombinant IL2 Inducible T-Cell Kinase (ITK) Positive Control; Immunogen; SDS-PAGE; WB.
RPH774Mu02 Recombinant IL2 Inducible T-Cell Kinase (ITK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH774Mu01 Polyclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) WB; IHC; ICC; IP.
PAH774Mu02 Polyclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) WB; IHC; ICC; IP.
LAH774Mu71 Biotin-Linked Polyclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) WB; IHC; ICC.
Assay Kits SEH774Mu ELISA Kit for IL2 Inducible T-Cell Kinase (ITK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IL2 Inducible T-Cell Kinase (ITK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IL2 Inducible T-Cell Kinase (ITK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IL2 Inducible T-Cell Kinase (ITK) CLIA Kit Customized Service Offer
n/a ELISA Kit for IL2 Inducible T-Cell Kinase (ITK) ELISA Kit Customized Service Offer
  1. "A novel human tyrosine kinase gene inducible in T cells by interleukin 2."FEBS Lett. 324:1-5(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q."Blood 82:1561-1572(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases."Biochim. Biophys. Acta 1645:123-132(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity."J. Biol. Chem. 272:25401-25408(1997) [PubMed] [Europe PMC] [Abstract]
  7. "CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail."Int. Immunol. 10:1009-1016(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Tec kinases: a family with multiple roles in immunity."Immunity 12:373-382(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav."Biochemistry 41:10732-10740(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor."J. Immunol. 170:3971-3976(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk."Immunity 21:189-201(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton."J. Immunol. 174:1385-1392(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors."J. Biol. Chem. 281:38529-38534(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  16. "SH2-dependent autophosphorylation within the Tec family kinase Itk."J. Mol. Biol. 391:164-177(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells."EMBO J. 30:3160-3172(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of the BTK motif and the SH3 domain of tyrosine-protein kinase ITK from human."Submitted (OCT-2007) to the PDB data bank
  21. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation."J. Clin. Invest. 119:1350-1358(2009) [PubMed] [Europe PMC] [Abstract]