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Inter Alpha-Globulin Inhibitor H5 (ITIH5)

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Inter-alpha-trypsin inhibitor heavy chain H5

Inter Alpha-Globulin Inhibitor H5 (ITIH5)
CCC H775
HGNC 21449
MGI 1925751
PubMed 24265292
UniProt Q86UX2
ITIH5 encodes a deduced 942-amino acid protein that contains 2 conserved ITIH domains: a vault inter-alpha-trypsin (VIT) domain and a von Willebrand type A (VWA) domain. ITIH5 also contains a putative 18-amino acid signal peptide and a conserved cleavage site in the C-terminal segment, containing a multicopper oxidase domain, which is cleaved during chain assembly.
ITIH5 transcript at highest levels in placenta, at less abundant levels in mammary gland and ovary, and at barely detectable levels in all other tissues tested. Real-time PCR confirmed the predominant expression of ITIH5 in placenta.ITIH5 expression was undetected by real-time PCR in all breast carcinoma and epithelial cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH775Hu01 Recombinant Inter Alpha-Globulin Inhibitor H5 (ITIH5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH775Hu01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H5 (ITIH5) WB; IHC; ICC; IP.
MAH775Hu21 Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H5 (ITIH5) WB; IHC; ICC; IP.
Assay Kits SEH775Hu ELISA Kit for Inter Alpha-Globulin Inhibitor H5 (ITIH5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH775Mu01 Recombinant Inter Alpha-Globulin Inhibitor H5 (ITIH5) Positive Control; Immunogen; SDS-PAGE; WB.
RPH775Mu02 Recombinant Inter Alpha-Globulin Inhibitor H5 (ITIH5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH775Mu01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H5 (ITIH5) WB
PAH775Mu02 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H5 (ITIH5) WB; IHC; ICC; IP.
Assay Kits SEH775Mu ELISA Kit for Inter Alpha-Globulin Inhibitor H5 (ITIH5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer."Cancer Lett. 204:69-77(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]