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Inter Alpha-Globulin Inhibitor H2 (ITIH2)

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H2P; SHAP; IGHEP2; Serum-derived hyaluronan-associated protein; Inter-alpha-trypsin inhibitor complex component II

Inter Alpha-Globulin Inhibitor H2 (ITIH2)
CCC H778
HGNC 6167
MGI 96619
PubMed 1385302
UniProt P19823
Wiki ITIH2
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain and a variable number of heavy chains. By screening a liver expression library with antibodies against ITI chains, Salier et al. (1987) isolated a partial cDNA encoding an ITI heavy chain. Diarra-Mehrpour et al. (1989) analyzed the in vitro translation product of liver mRNAs hybrid-selected by this partial cDNA, lambda-HUHITI(9+33), and determined that it encoded the H2 (ITIH2) heavy chain. Enghild et al. (1989) found that one ITI member is composed of the mature ITIH1 (HC1) and ITIH2 (HC2) heavy chains and a 30-kD subunit. Bost et al. (1993) stated that the 30-kD subunit is bikunin .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH778Hu01 Recombinant Inter Alpha-Globulin Inhibitor H2 (ITIH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH778Hu01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) WB; IHC; ICC; IP.
MAH778Hu21 Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) WB; IHC; ICC; IP.
Assay Kits SEH778Hu ELISA Kit for Inter Alpha-Globulin Inhibitor H2 (ITIH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inter Alpha-Globulin Inhibitor H2 (ITIH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH778Mu ELISA Kit for Inter Alpha-Globulin Inhibitor H2 (ITIH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inter Alpha-Globulin Inhibitor H2 (ITIH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H2 (ITIH2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH778Ra ELISA Kit for Inter Alpha-Globulin Inhibitor H2 (ITIH2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex."FEBS Lett. 229:63-67(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI."Proc. Natl. Acad. Sci. U.S.A. 84:8272-8276(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain."Biol. Chem. Hoppe-Seyler 369:15-18(1988) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins."Biol. Chem. Hoppe-Seyler 368:963-970(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan."J. Biol. Chem. 264:15975-15981(1989) [PubMed] [Europe PMC] [Abstract]
  7. "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A."Biol. Chem. Hoppe-Seyler 373:1009-1018(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin."J. Biol. Chem. 268:8711-8716(1993) [PubMed] [Europe PMC] [Abstract]
  9. "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."Biochemistry 33:7423-7429(1994) [PubMed] [Europe PMC] [Abstract]
  10. "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor."J. Biol. Chem. 268:26725-26730(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor."Eur. J. Biochem. 221:881-888(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Glycosylation pattern of human inter-alpha-inhibitor heavy chains."Biochem. J. 333:749-756(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2."Biochemistry 37:408-416(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]