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Inter Alpha-Globulin Inhibitor H1 (ITIH1)

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H1P; IATIH; ITIH; IGHEP1; Serum-derived hyaluronan-associated protein; Inter-alpha-trypsin inhibitor complex component III

Inter Alpha-Globulin Inhibitor H1 (ITIH1)
CCC H779
HGNC 6166
MGI 96618
PubMed 10100603
RGD 1306099
UniProt P19827
Wiki ITIH1
Salier et al. (1987) characterized cDNAs for the H chain of IATI. Diarra-Mehrpour et al. (1989) showed that human poly(A)-rich RNAs hybrid-selected with various heavy-chain-encoding cDNA clones translate 3 different heavy chains, designated H1 (M(r) 92,000), H2 (ITIH2), and H3 (ITIH3). Two previously characterized heavy-chain cDNA clones were found to correspond to the H1 and H2 chains. The deduced amino acid sequence of the H3 chain was found to be highly similar to those of the H1 (54%) and H2 (44%) chains. Diarra-Mehrpour et al. (1992) used a PCR-based cloning approach and cDNA library screening to isolate the full-length cDNA H1. The results of Northern blot analysis by Bost et al. (1993) indicated that the 2.9-kb ITIH1 mRNA is expressed only in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH779Hu01 Recombinant Inter Alpha-Globulin Inhibitor H1 (ITIH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH779Hu01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H1 (ITIH1) WB; IHC
MAH779Hu21 Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H1 (ITIH1) WB; IHC; ICC; IP.
Assay Kits SEH779Hu ELISA Kit for Inter Alpha-Globulin Inhibitor H1 (ITIH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH779Mu01 Recombinant Inter Alpha-Globulin Inhibitor H1 (ITIH1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH779Mu02 Recombinant Inter Alpha-Globulin Inhibitor H1 (ITIH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH779Mu01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H1 (ITIH1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Inter Alpha-Globulin Inhibitor H1 (ITIH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inter Alpha-Globulin Inhibitor H1 (ITIH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH779Ra01 Recombinant Inter Alpha-Globulin Inhibitor H1 (ITIH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH779Ra01 Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H1 (ITIH1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Inter Alpha-Globulin Inhibitor H1 (ITIH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inter Alpha-Globulin Inhibitor H1 (ITIH1) ELISA Kit Customized Service Offer
  1. "Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1."Biochim. Biophys. Acta 1132:114-118(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene."Eur. J. Biochem. 218:283-291(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A."Biol. Chem. Hoppe-Seyler 373:1009-1018(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan."J. Biol. Chem. 264:15975-15981(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related."Eur. J. Biochem. 181:571-576(1989) [PubMed] [Europe PMC] [Abstract]
  9. "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor."J. Biol. Chem. 268:26725-26730(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI."Proc. Natl. Acad. Sci. U.S.A. 84:8272-8276(1987) [PubMed] [Europe PMC] [Abstract]
  11. "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins."Biol. Chem. Hoppe-Seyler 368:963-970(1987) [PubMed] [Europe PMC] [Abstract]
  12. "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor."Eur. J. Biochem. 221:881-888(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes."Biochim. Biophys. Acta 1219:551-554(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Glycosylation pattern of human inter-alpha-inhibitor heavy chains."Biochem. J. 333:749-756(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2."Biochemistry 37:408-416(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism."Hum. Genet. 95:435-436(1995) [PubMed] [Europe PMC] [Abstract]