Iroquois Homeobox Protein 4 (IRX4)

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Homeodomain protein IRXA3

Iroquois Homeobox Protein 4 (IRX4)
Mouse and human IRX4 cDNAs encode deduced proteins of 515 and 519 amino acids, respectively, which share 83% sequence identity. In situ hybridization and Northern blot analysis in mice demonstrated that Irx4 transcripts are present in the developing central nervous system, skin, and vibrissae, but are predominantly expressed in the cardiac ventricles. In mice at embryonic day (E) 7.5, Irx4 transcripts are found in the chorion and at low levels in a discrete anterior domain of the cardiac primordia. During the formation of the linear heart tube and its subsequent looping, Irx4 expression is restricted to the ventricular segment. Throughout all subsequent stages in which the chambers of the heart become morphologically distinct and into adulthood, cardiac Irx4 expression is found exclusively in the ventricular myocardium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iroquois Homeobox Protein 4 (IRX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iroquois Homeobox Protein 4 (IRX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iroquois Homeobox Protein 4 (IRX4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iroquois Homeobox Protein 4 (IRX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iroquois Homeobox Protein 4 (IRX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iroquois Homeobox Protein 4 (IRX4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iroquois Homeobox Protein 4 (IRX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iroquois Homeobox Protein 4 (IRX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iroquois Homeobox Protein 4 (IRX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iroquois Homeobox Protein 4 (IRX4) ELISA Kit Customized Service Offer
  1. "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand."Dev. Biol. 217:266-277(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility."Hum. Mol. Genet. 21:2076-2085(2012) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]