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Integrator Complex Subunit 8 (INTS8)

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INT8; C8orf52; Protein kaonashi-1

Integrator Complex Subunit 8 (INTS8)
CCC H798
HGNC 26048
MGI 1919906
PubMed 16239144
UniProt Q75QN2
Wiki INTS8
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. INTS8 is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs.
INTS8 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2) . By SDS-PAGE of proteins that copurified with INTS11 (CPSF3L) in HEK293 cells, Baillat et al. (2005) identified INTS8 as a subunit of the Integrator complex.The International Radiation Hybrid Mapping Consortium mapped the INTS8 gene to chromosome 8 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 8 (INTS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 8 (INTS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 8 (INTS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 8 (INTS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 8 (INTS8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 8 (INTS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 8 (INTS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 8 (INTS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 8 (INTS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 8 (INTS8) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]