Integrator Complex Subunit 9 (INTS9)
[Edit]RC74; CPSF2L; Protein related to CPSF subunits of 74 kDa
INTS9 encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.
The deduced 658-amino acid protein contains mutations within the catalytic histidine motif, suggesting that it is inactive. Fluorescence- and epitope-tagged INTS9 was expressed exclusively in the nucleus of transfected HeLa cells.full-length RC74 interacted with C-terminal fragments of RC68 (CPSF3L) and full-length importin-alpha (KPNA2).
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Integrator Complex Subunit 9 (INTS9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Integrator Complex Subunit 9 (INTS9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Integrator Complex Subunit 9 (INTS9) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Integrator Complex Subunit 9 (INTS9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Integrator Complex Subunit 9 (INTS9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Integrator Complex Subunit 9 (INTS9) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Integrator Complex Subunit 9 (INTS9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Integrator Complex Subunit 9 (INTS9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Integrator Complex Subunit 9 (INTS9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Integrator Complex Subunit 9 (INTS9) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
- "A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100."Mol. Cell. Biol. 25:1489-1500(2005) [PubMed] [Europe PMC] [Abstract]