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Integrator Complex Subunit 10 (INTS10)

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INT10; C8orf35

Integrator Complex Subunit 10 (INTS10)
CCC H800
HGNC 25548
MGI 1918135
RGD 1304711
UniProt Q9NVR2
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. INTS7 is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs.
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2).By SDS-PAGE of proteins that copurified with INTS11 (CPSF3L) in HEK293 cells, Baillat et al. (2005) identified INTS10 as a subunit of the Integrator complex.The International Radiation Hybrid Mapping Consortium mapped the INTS10 gene to chromosome 8.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 10 (INTS10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 10 (INTS10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 10 (INTS10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 10 (INTS10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 10 (INTS10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 10 (INTS10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 10 (INTS10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 10 (INTS10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 10 (INTS10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 10 (INTS10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 10 (INTS10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 10 (INTS10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 10 (INTS10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 10 (INTS10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 10 (INTS10) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]