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Inhibitor Of Growth Family, Member 4 (ING4)

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My036; p29ING4

Inhibitor Of Growth Family, Member 4 (ING4)
CCC H806
HGNC 19423
MGI 107307
PubMed 19187765
RGD 1309407
UniProt Q9UNL4
Wiki ING4
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling.
This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.ING4 was significantly reduced in gliomas as compared with normal human brain tissue, and the extent of reduction correlated with the progression from lower to higher grades of tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 4 (ING4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 4 (ING4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 4 (ING4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 4 (ING4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 4 (ING4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 4 (ING4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 4 (ING4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 4 (ING4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 4 (ING4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 4 (ING4) ELISA Kit Customized Service Offer
  1. "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity."Cancer Res. 63:2373-2378(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility."J. Biol. Chem. 281:34677-34686(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene."Oncogene 26:5247-5257(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells."FEBS Lett. 570:7-12(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis."Nature 428:328-332(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer."Proc. Natl. Acad. Sci. U.S.A. 101:16251-16256(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear localization signal of ING4 plays a key role in its binding to p53."Biochem. Biophys. Res. Commun. 331:1032-1038(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)."Proc. Natl. Acad. Sci. U.S.A. 102:7481-7486(2005) [PubMed] [Europe PMC] [Abstract]
  11. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  12. "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 442:96-99(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53."J. Biol. Chem. 286:17069-17078(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular basis of histone H3K4me3 recognition by ING4."J. Biol. Chem. 283:15956-15964(2008) [PubMed] [Europe PMC] [Abstract]
  16. "ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation."Mol. Cell 33:248-256(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins."J. Biol. Chem. 287:10876-10884(2012) [PubMed] [Europe PMC] [Abstract]