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Inhibitor Of Growth Family, Member 3 (ING3)

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Eaf4; MEAF4; p47ING3

Inhibitor Of Growth Family, Member 3 (ING3)
CCC H807
HGNC 14587
MGI 1919027
PubMed 24066152
RGD 1310556
UniProt Q9NXR8
Wiki ING3
ING3 is a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.The ING3 gene encodes a predicted 418-amino acid protein with a putative molecular mass of 47 kD. The protein shows high homology with other members of the ING family within the PHD zinc finger domain and weak overall homology with ING1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 3 (ING3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 3 (ING3) Monoclonal Antibody Customized Service Offer
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n/a ELISA Kit for Inhibitor Of Growth Family, Member 3 (ING3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 3 (ING3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 3 (ING3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 3 (ING3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 3 (ING3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 3 (ING3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 3 (ING3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 3 (ING3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 3 (ING3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 3 (ING3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 3 (ING3) ELISA Kit Customized Service Offer
  1. "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis."Oncogene 22:343-350(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The highly conserved and multifunctional NuA4 HAT complex."Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  9. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 442:96-99(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers."Plant J. 58:511-524(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "ANP32E is a histone chaperone that removes H2A.Z from chromatin."Nature 505:648-653(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of PHD domain in inhibitor of growth protein 3 (ING3) antigen 7."Submitted (NOV-2006) to the PDB data bank
  15. "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers."Oncogene 21:4462-4470(2002) [PubMed] [Europe PMC] [Abstract]