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Inhibitor Of Growth Family, Member 2 (ING2)

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ING1L; p33ING2; p32; Inhibitor of growth 1-like protein

Inhibitor Of Growth Family, Member 2 (ING2)
CCC H808
HGNC 6063
MGI 1916510
PubMed 16728974
RGD 1307347
UniProt Q9H160
Wiki ING2
The deduced 280-amino acid ING1L protein shares 58.9% sequence identity with ING1. ING1L contains a C-terminal PHD-type zinc finger domain. The PHD zinc finger was first identified in 2 closely related plant homeodomain-containing proteins. It is a cys4-his-cys3 (C4HC3)-type motif spanning 50 to 80 amino acids. PHD zinc fingers have been found in a number of proteins implicated in chromatin-mediated transcriptional control.
Northern blot analysis of normal human tissues detected ubiquitous expression of 1.3- and 1.5-kb ING1L transcripts. The authors found that ING1L expression was significantly higher in colon tumors than in the adjacent normal colon tissue.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 2 (ING2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 2 (ING2) Monoclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 2 (ING2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 2 (ING2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 2 (ING2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 2 (ING2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 2 (ING2) ELISA Kit Customized Service Offer
  1. "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor."Cytogenet. Cell Genet. 83:232-235(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53."Proc. Natl. Acad. Sci. U.S.A. 98:9671-9676(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis."FEBS Lett. 582:3868-3874(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)."Mol. Cell. Biol. 22:835-848(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor." Cell 114:99-111(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding."J. Biol. Chem. 281:28831-28836(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  11. "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 442:96-99(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Sumoylation of ING2 regulates the transcription mediated by Sin3A."Oncogene 29:5946-5956(2010) [PubMed] [Europe PMC] [Abstract]