Interleukin Enhancer Binding Factor 2 (ILF2)

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NF45; Nuclear factor of activated T-cells 45 kDa

Interleukin Enhancer Binding Factor 2 (ILF2)
NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.
The NF45 gene encodes a 405-amino acid polypeptide with distant similarity to DNA topoisomerase II and a prokaryotic RNA polymerase that melts DNA to initiate transcription. NF45 and NF90 were expressed in several cell types, including both unstimulated and stimulated Jurkat T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin Enhancer Binding Factor 2 (ILF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin Enhancer Binding Factor 2 (ILF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin Enhancer Binding Factor 2 (ILF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin Enhancer Binding Factor 2 (ILF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin Enhancer Binding Factor 2 (ILF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin Enhancer Binding Factor 2 (ILF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin Enhancer Binding Factor 2 (ILF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin Enhancer Binding Factor 2 (ILF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin Enhancer Binding Factor 2 (ILF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin Enhancer Binding Factor 2 (ILF2) ELISA Kit Customized Service Offer
  1. "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90."J. Biol. Chem. 269:20691-20699(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45."J. Biol. Chem. 273:2136-2145(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity."J. Biol. Chem. 274:34598-34604(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Directed proteomic analysis of the human nucleolus."Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells."Mol. Cell. Biol. 22:343-356(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G."Biochim. Biophys. Acta 1774:1339-1350(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense."Genes Dev. 24:2640-2653(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]