Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)

IL1RAPL2 is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation.

The 307-amino acid cytoplasmic tail of the predicted 686-amino acid protein contains an additional 120 to 130 residues beyond the THD, like IL1R8 (IL1RAPL1) but unlike other IL1Rs. Evolutionary sequence analysis suggested that IL1R8 and IL1R9 probably form a functionally distinct subset of orphan receptors in the IL1R superfamily. Northern blot analysis revealed expression of a 5.5-kb transcript in fetal brain.