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Exosome Component 5 (EXOSC5)

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RRP41B; RRP46; Rrp46p; hRrp46p; p12B; CML28; Chronic myelogenous leukemia tumor antigen 28; Ribosomal RNA-processing protein 46

Exosome Component 5 (EXOSC5)
CCC H825
HGNC 24662
MGI 107889
PubMed 19460752
RGD 1307861
UniProt Q9NQT4
Wiki EXOSC5
The deduced 235-amino acid RRP46 protein is 89% and approximately 28% identical to the mouse and yeast sequences, respectively. Western blot analysis and immunofluorescence microscopy showed expression of a 26-kD protein in the nucleus, with additional forms expressed in the cytoplasm and the highest concentration in nucleolus.
The CSL4 protein, but not mutant forms lacking N- or C-terminal residues, interacted directly with RRP42 and RRP46. The deletion mutants were also unable to interact with the exosome. RRP42 and RRP46 did not interact with each other.ARE recognition required certain ARE-binding proteins that could interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 5 (EXOSC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 5 (EXOSC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 5 (EXOSC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 5 (EXOSC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 5 (EXOSC5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 5 (EXOSC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 5 (EXOSC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 5 (EXOSC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 5 (EXOSC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 5 (EXOSC5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 5 (EXOSC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 5 (EXOSC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 5 (EXOSC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 5 (EXOSC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 5 (EXOSC5) ELISA Kit Customized Service Offer
  1. "Three novel components of the human exosome."J. Biol. Chem. 276:6177-6184(2001) [PubMed] [Europe PMC] [Abstract]
  2. "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells."Cancer Res. 62:5517-5522(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases."Genes Dev. 13:2148-2158(1999) [PubMed] [Europe PMC] [Abstract]
  6. "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."Cell 107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements."EMBO J. 21:165-174(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Protein-protein interactions of hCsl4p with other human exosome subunits."J. Mol. Biol. 315:809-818(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA."Proc. Natl. Acad. Sci. U.S.A. 104:151-156(2007) [PubMed] [Europe PMC] [Abstract]
  10. "p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein."Proc. Natl. Acad. Sci. U.S.A. 105:4352-4357(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates."Cell 144:353-363(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs."FASEB J. 25:2757-2769(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Reconstitution, activities, and structure of the eukaryotic RNA exosome."Cell 127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
  18. ErratumCell 131:188-189(2007)