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Interferon Induced Transmembrane Protein 3 (IFITM3)

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1-8U; IP15; DSPA2b; Dispanin subfamily A member 2b; Interferon-inducible protein 1-8U

Interferon Induced Transmembrane Protein 3 (IFITM3)
CCC H830
HGNC 5414
MGI 1913391
PubMed 22046135
RGD 1595844
UniProt Q01628
Wiki IFITM3
Genomic sequence analysis determined that all 3 IFITMs contain 2 exons, with the interferon-stimulable response elements (ISREs) in the immediately 5-prime flanking sequence of the promoter/enhancer region. Unlike IFITM1, which has an ISRE and 2 CCAAT boxes but lacks a TATA box, IFITM2 and IFITM3 have 2 ISREs and no TATA or CCAAT boxes.
Sequence analysis predicted that the 133-amino acid IFITM3 protein, which is approximately 90% identical to IFITM2, has an N-terminal signal sequence, 3 potential phosphorylation sites, and a C-terminal leucine zipper. Sequence variability is greatest at the C terminus. Immunoblot analysis showed that in response to IFNA, all 3 IFITMs were expressed as 14-kD proteins that could be further resolved by isoelectric focusing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH830Hu01 Recombinant Interferon Induced Transmembrane Protein 3 (IFITM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Polyclonal Antibody Customized Service Offer
Assay Kits SCH830Hu CLIA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) Chemiluminescent immunoassay for Antigen Detection.
SEH830Hu ELISA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 3 (IFITM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 3 (IFITM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 3 (IFITM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Transmembrane Protein 3 (IFITM3) ELISA Kit Customized Service Offer
  1. "Molecular analysis of a human interferon-inducible gene family."Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
  2. "IFITM3 restricts the morbidity and mortality associated with influenza." Nature 484:519-523(2012) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."Oncogene 29:752-762(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3."Nat. Chem. Biol. 6:610-614(2010) [PubMed] [Europe PMC] [Abstract]
  11. "The small interferon-induced transmembrane genes and proteins."J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The IFITM proteins inhibit HIV-1 infection."J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
  13. ErratumJ. Virol. 85:4043-4043(2011)
  14. "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry."PLoS Pathog. 7:E1002337-E1002337(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."PLoS Pathog. 7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]
  16. "S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."J. Biol. Chem. 287:19631-19641(2012) [PubMed] [Europe PMC] [Abstract]
  17. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The dispanins: a novel gene family of ancient origin that contains 14 human members."PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
  19. "The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."Cell Host Microbe 13:452-464(2013) [PubMed] [Europe PMC] [Abstract]