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Zinc Fingers And Homeoboxes Protein 3 (ZHX3)

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TIX1; Triple Homeobox 1

Zinc Fingers And Homeoboxes Protein 3 (ZHX3)
CCC H845
HGNC 15935
MGI 2444772
PubMed 12659632
RGD 631431
UniProt Q9H4I2
Wiki ZHX3
ZHX3 encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. ZHX3 encodes a 956-amino acid protein with a predicted molecular mass of 104.7 kD. It has 2 zinc finger domains, 5 homeodomains, a glu-rich region, and 2 nuclear localization signals. ZHX3 and ZHX1 share 34.4% amino acid identity. Northern blot analysis detected transcripts of 9.4, 7.3, 5.0, and 4.6 kb in all tissues examined. Immunofluorescence showed that full-length ZHX3 localized to the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 3 (ZHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 3 (ZHX3) ELISA Kit Customized Service Offer
  1. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation."Stem Cells Dev. 20:1539-1547(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the homeobox domain of zinc fingers and homeoboxes protein 3 (triple homeobox 1 protein)."Submitted (JUN-2006) to the PDB data bank
  13. "Solution structure of the second homeobox domain of human zinc fingers and homeoboxes protein 3."Submitted (FEB-2009) to the PDB data bank