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Zinc Fingers And Homeoboxes Protein 2 (ZHX2)

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AFR1; RAF; Alpha-fetoprotein regulator 1

Zinc Fingers And Homeoboxes Protein 2 (ZHX2)
CCC H846
HGNC 18513
MGI 2683087
PubMed 20160197
RGD 727926
UniProt Q9Y6X8
Wiki ZHX2
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. ZHX2 encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
The deduced 837-amino acid protein shares about 40% identity with mouse Zhx1. RT-PCR ELISA detected expression in all tissues examined, with highest levels in ovary, followed by lung, heart, kidney, brain, and liver. Intermediate expression was detected in pancreas, spleen, testis, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Fingers And Homeoboxes Protein 2 (ZHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Fingers And Homeoboxes Protein 2 (ZHX2) ELISA Kit Customized Service Offer
  1. "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor."Biochem. J. 373:747-757(2003) [PubMed] [Europe PMC] [Abstract].
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome."J. Biol. Chem. 281:39681-39692(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Solution structure of the third homeobox domain of zinc fingers and homeoboxes protein 2."Submitted (OCT-2006) to the PDB data bank
  8. "Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains."BMC Struct. Biol. 10:13-13(2010) [PubMed] [Europe PMC] [Abstract]