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Homeobox Protein B1 (HOXB1)

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HOX2; HOX2I; Hox-2.9

Homeobox Protein B1 (HOXB1)
CCC H891
HGNC 5111
MGI 96182
PubMed 22485187
RGD 1310298
UniProt P14653
Wiki HOXB1
HOXB1 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.Hoxb genes are first activated in a temporal colinear fashion in precursors located in the epiblast lateral to the primitive streak. Their data suggested that colinear activation of Hoxb genes regulates the flux of cells from the epiblast to the streak and thus directly controls the establishment of the genes' characteristic nested expression domains in the somites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein B1 (HOXB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein B1 (HOXB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein B1 (HOXB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein B1 (HOXB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein B1 (HOXB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein B1 (HOXB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein B1 (HOXB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein B1 (HOXB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein B1 (HOXB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein B1 (HOXB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein B1 (HOXB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein B1 (HOXB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein B1 (HOXB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein B1 (HOXB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein B1 (HOXB1) ELISA Kit Customized Service Offer
  1. "The human HOX gene family."Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of human class I homeobox genes."Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation."Cell 96:587-597(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A genetic polymorphism in the human HOXB1 homeobox gene implying a 9bp tandem repeat in the amino-terminal coding region."Hum. Mutat. 12:363-363(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders."Teratology 62:393-405(2000) [PubMed] [Europe PMC] [Abstract]
  8. "HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1(-/-) mice."Am. J. Hum. Genet. 91:171-179(2012) [PubMed] [Europe PMC] [Abstract]