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Histidine Triad Nucleotide Binding Protein 1 (HINT1)

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HINT; PKCI1; PRKCNH1; Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1

Histidine Triad Nucleotide Binding Protein 1 (HINT1)
CCC H908
HGNC 4912
MGI 1321133
PubMed 22961002
RGD 1593411
UniProt P49773
Wiki HINT1
PRKCNH1 is a member of a family of small proteins found in several species that inhibit PKC activity in the presence of the 14-3-3 proteins.the PKCI1 protein interacts with the regulatory domain of PKC-beta in the yeast 2-hybrid system. In the same system, PKCI1 also interacts with the ataxia-telangiectasia group D protein, which is mutant in ataxia-telangiectasia . PKCI1 was a potent inhibitor of PKC.
The authors commented that the protein is a member of the HIT family of proteins; the term HIT refers to the histidine triad near the C terminus in this family (i.e., his110, his112, and his114 in the human PKCI1 sequence). They noted that FHIT, a putative tumor suppressor gene, is a PKCI1 homolog.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histidine Triad Nucleotide Binding Protein 1 (HINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histidine Triad Nucleotide Binding Protein 1 (HINT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidine Triad Nucleotide Binding Protein 1 (HINT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histidine Triad Nucleotide Binding Protein 1 (HINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEH908Mu ELISA Kit for Histidine Triad Nucleotide Binding Protein 1 (HINT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histidine Triad Nucleotide Binding Protein 1 (HINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidine Triad Nucleotide Binding Protein 1 (HINT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEH908Ra ELISA Kit for Histidine Triad Nucleotide Binding Protein 1 (HINT1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)."Genomics 36:151-156(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor."Proc. Natl. Acad. Sci. U.S.A. 92:7824-7828(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins."Proc. Natl. Acad. Sci. U.S.A. 93:5357-5362(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions."J. Biol. Chem. 280:15356-15361(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription."J. Cell Sci. 118:3117-3129(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity."J. Biol. Chem. 281:27356-27366(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate."J. Biol. Chem. 282:15137-15147(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src."J. Biol. Chem. 284:5265-5276(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells."Cell Cycle 11:2206-2215(2012) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structure-based analysis of catalysis and substrate definition in the HIT protein family."Science 278:286-290(1997) [PubMed] [Europe PMC] [Abstract]
  18. "A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution."Acta Crystallogr. F 68:883-888(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor."J. Phys. Chem. B 116:6798-6805(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia." Nat. Genet. 44:1080-1083(2012) [PubMed] [Europe PMC] [Abstract]