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Guanylate Kinase 1 (GUK1)

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GMK; GMP kinase

Guanylate Kinase 1 (GUK1)
CCC H939
HGNC 4693
MGI 95871
PubMed 16832584
RGD 1309638
UniProt Q16774
Wiki GUK1
Guanylate kinase (EC 2.7.4.8) catalyzes the transfer of phosphate from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) or dGMP. This enzyme functions in the recovery of cGMP and is, therefore, thought to regulate the supply of guanine nucleotides to signal transduction pathways. See GUK2 and GUK3 , isoforms believed to be determined by separate loci.
Brady et al. (1996) cloned human and mouse cDNAs of GUK1. They reported that the human gene predicts a protein of 197 amino acids with a mass of 21.7 kD. They found that the 1-kb message was ubiquitously expressed. Brady et al. (1996) published a computer model of GUK1 tertiary structure designed to be used in the development of chemotherapy drugs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Kinase 1 (GUK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Kinase 1 (GUK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Kinase 1 (GUK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Kinase 1 (GUK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Kinase 1 (GUK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Kinase 1 (GUK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Kinase 1 (GUK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Kinase 1 (GUK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Kinase 1 (GUK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Kinase 1 (GUK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Kinase 1 (GUK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Kinase 1 (GUK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Kinase 1 (GUK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Kinase 1 (GUK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Kinase 1 (GUK1) ELISA Kit Customized Service Offer
  1. "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation."FEBS Lett. 385:185-188(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, characterization, and modeling of mouse and human guanylate kinases."J. Biol. Chem. 271:16734-16740(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]