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Guanylate Cyclase 1 Alpha 3 (GUCY1a3)

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GC-SA3; GUC1A3; GUCA3; GUCSA3; Guanylate cyclase soluble subunit alpha-3; Soluble guanylate cyclase large subunit

Guanylate Cyclase 1 Alpha 3 (GUCY1a3)
CCC H945
HGNC 4685
MGI 1926562
PubMed 24213632
RGD 68436
UniProt Q02108
Wiki GUCY1A3
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit, such as alpha-1 (GUCY1A3), and a beta subunit, typically beta-1 (GUCY1B3), catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
highest expression of the alpha-2/beta-1 isoform was in brain, with significant expression in lung and lower expression in all other tissues examined. Levels of the alpha-1/beta-1 and alpha-2/beta-1 isoforms were comparable in brain, but alpha-1/beta-1 was the predominant isoform in all other tissues examined. Overall, lung had the highest amount of NOGC content.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase 1 Alpha 3 (GUCY1a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase 1 Alpha 3 (GUCY1a3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain."FEBS Lett. 304:83-88(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Human soluble guanylate cyclase: functional expression and revised isoenzyme family."Biochem. J. 335:51-57(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]